100 Most Important Nepal Pharmacy Council Exam past Questions (part-1)

 Nepal Pharmacy Council Past Question/Bachelor in Pharmacy licenses Exam Questions

1. Are most of the drugs absorbed by Mechanisms?
a. Active Transport
b. Passive diffusion (90%)
c. Endocytosis
d. Pinocytosis
2. Which of the following routes of administration gives 100%Bioavailability?
a. Oral
b. Intraveneous (I/V)
c. Intramuscular
d. Rectal Route
3. Which route of administration shows hepatic first-pass effect?
a. Rectal
b. Oral
c. IV
d. Sublingual
4. What is the feature of the Sublingual route of administration?
a. The absorption rate is slower
b. Preety Fast absorption
c. Hepatic first pass effect
d. Less sideeffects
5. Acidic drugs are best absorbed from?
a. Oral cavity
b. Stomach
c. Intestine
d. Esophagus
6. Hyoscine Is absorbed from?
a. Intestine
b. Stomach
c. Esophagus
d. Oral cavity
7. Aspirin is absorbed from?
a. Intestine
b. Stomach
c. Esophagus
d. Oral cavity
8. Most of the drugs are absorbed from?
a. Stomach
b. Distal small Intestine (Ileum)
c. Proximal Small Intestine
d. Large intestine

9. Alkalization of urine hastens/favors the excretion of?
a. Weakly basic drug
b. Weakly acidic drug
c. Neutral salts
d. Strong basic drug
10. Most important organ for the Biotransformation(Metabolism) of drug is ?
a. Stomach
b. Liver
c. Kidney
d. Intestine
11. Which of the following organs are major for the excretion of drugs?
a. Kidney and Rectum
b. Stomach and Kidney
c. Skin and liver
d. Lungs and Liver
12. A Major Microsomal enzyme for the Metabolism of drugs is?
a. Cytochrome P450 (CYP-450)
b. Decarboxylase
c. Transferase
d. Transpeptidase
13. Biological oxidation and reduction are the phases…… of Metabolism? (Oxidation is a common Phase)
a. 1
b. 2
c. 3
d. 4
14. Which phase of Metabolism is known as the Conjugation phase?
a. 1
b. 2
c. 3
d. 4
15. Which of the following is not the principle of drug action(Pharmacodynamic)?
a. Stimulation
b. Depression
c. Simulation
d. Irritation
16. Rate and extent of drug that reaches systemic circulation in UNCHANGED form is called?
a. Absorption
b. Metabolism
c. Excretion
d. Bioavailability
17. The Bioavailability is denoted by …… symbol?
a. BA
b. F (Fraction)
c. BE
d. M
18. Therapeutic index (Window) measures
a. Potency
b. Safety
c. Toxicity
d. Efficacy
19. Drugs that bind to the receptors and are incapable of producing any pharmacological responses are called?
a. Agonist
b. Antagonist
c. Partial Agonist
d. Intrinsic Activity
20. Which of the following is the dose-dependent ADR?
a. Type A
b. Type B (Unpredictable)
c. Type C
d. Type D
21. Posology is?
a. Study of poison
b. Study of Dose
c. Study about Toxins
d. Study about the pharmacological action of drugs
22. Which of the following terms is known as "What the body does to the drug"?
a. Pharmacodynamics
b. Pharmacokinetics (Movement of drug in body)
c. Pharmacovigilance
d. Posology
23. Triple therapy is used for the management of?
a. H.pylori Infection
b. Tuberculosis
c. Leprosy
d. Dermatitis
24. Which of the following antibiotics is NOT used in triple therapy?
a. Metronidazole
b. Clarithromycine
c. Tetracycline
d. Amoxicillin
25. The action of simethicone(Dimethicone) in GI disorder is?
a. Antacid
b. Ulcer protective
c. Antimicrobial
d. Anti-Flatulant
26. Antacids(Increases the PH- Upto 6.5) should not be taken with?
a. H2 Receptor antagonist
b. Proton Pump Inhibitors
c. Sucralfate (Working PH Below 4.5)
d. Anti- cholinergic
27. Which of the following H2 receptor antagonists has the inhibitory effect on Cytochrome P450?
a. Ranitidine
b. Famotidine
c. Cimetidine
d. Roxatadine
28. What is the full form of PPI?
a. Protein Pump Inhibitor
b. Proton Pump Inhibitor
c. Proton Pump Inducer
d. Protein Pump Inducer
29. An example of a systemic antacid is?
a. Aluminum hydroxide
b. Sodium Bicarbonate (NaHCO3)
c. Magnesium hydroxide
d. Magnesium Trisilicate
30. Which of the following Drugs is moisture sensitive?
a. Famotidine
b. Ranitidine
c. Roxatadine
d. Cimetidine
31. The most common Market available Combination form of Aluminum hydroxide and Magnesium Hydroxide is?
a. Megalderate
b. Co-trimoxazole
c. Naloxone
d. Metronidazole
32. Does aspirin act by blocking the enzyme?
a. Lipooxygenase
b. Cyclooxygenase (COX)
c. Phospholipase
d. Transpeptidase
33. Hepatotoxic metabolites are secreted by?
A. Tetracycline
B. Ranitidine
C. Paracetamol
D. Allopurinol
34. The antidote for paracetamol is?
A. Desferrioxamine
B. Activated charcoal
C. N-acetylcysteine
D. Naloxone
35. What is the common side effect of Ibuprofen?
A. Vomiting
B. GI irritation
C. Urinary retention
D. Myopathy
36. Excessive production of uric acid may cause?
A. Rheumatoid Arthritis
B. Gout
C. Peptic Ulcer
D. Hyperlipidaemia
37. Drug of choice for Acute gout is?
A. Allopurinol
B. Colchicine
C. Probenecid
D. NSAIDs(Indomethacin)
38. Which of the following drugs is used in Chronic gout?
B. Colchicine
C. Indomethacin
D. Ibuprofen
39. Which of the following is considered as the side effect of Colchicine?
A. Constipation
B. Diarrhoea
C. Vomiting
D. Nausea
40. Dose of Colchicine is?
A. 0.1 mg
B. 0.6mg (0.5)
C. 0.06mg
D. 10 mg
41. Gold salt is used for the management of?
A. Gout
B. Rheumatoid Arthritis
C. Myasthenia Gravis
D. Hyperlipidaemia
42. Which of the following is the male sex hormone?
A. Testosterone
B. Estrogen
C. Progestogen
D. Estradiol
43. The full of STDs :
A. Sexually Transmitted Diseases
44. Calcitonin is?
A. Thyroid hormone
B. Parathyroid hormone
C. Adrenal Hormone
D. Pituitary Hormone
45. Thyroid Stimulating Hormone (TSH) is secreted by?
A. Thyroid Gland (T3,T4, CALCITONIN)
B. Anterior Pituitary (Adenohypophysis)
C. Posterior Pituitary (Neurohypophysis)
D. Parathyroid gland
46. Which hormone is responsible for breast milk production (Mothers' milk)?
A. Oxytocin (Ejaculation of breast milk/Induction of labor)
B. Prolactin
C. Vasopressin
D. Calcitonin
47. Does Diabetes Insipidus occur due to a deficiency of?
A. Insulin
B. Glucagon
C. ADH( Anti-diuretic hormone)/Vasopressin
D. Somatostatin
48. In which type of Diabetes mellitus there is no secretion of Insulin?
A. Type 1
B. Type 2
C. Type 3
D. Type 4
49. Insulin is administered via route of administration?
A. I/M
B. I/V
C. S/C
D. Oral
50. Insulin is secreted by cells of the pancreas?
A. Alpha cells
B. Gamma cells
C. Delta cells
D. Beta cells
51. Diabetic Ketoacidosis is managed (Treated) by?
A. Lispro
B. Aspart
C. Glulisine
D. Regular Insulin (Short-acting insulin)
52. Regular Insulin is administered via …… route of administration?
A. S/C
B. I/M
C. I/V
D. Oral
53. The primary drug for Type 2 DM is?
A. Glyburide
B. Metformin
C. Acarbose
D. Sitagliptin
54. Metformin should be taken
A. Before meal
B. After Meal
C. With Meal
D. In Empty stomach
55. Insulin consists of amino acids?
A. 51
B. 41
C. 31
D. 21
56. Normal level of Cholesterol is?
A. < 250mg/dl
B. < 200mg/dl
C. <100mg/dl
D. <500mg/dl
57. What is the best time to take Statins?
A. In Morning
B. At bedtime (HS)
C. In Evening
D. Just at NOON time
58. Good Cholesterol is?
59. Which lipoproteins transport the Cholesterol from the Liver to peripheral sites?
60. Are all of the following fat-soluble vitamins EXCEPT?
A. Vitamin K
B. Vitamin C
C. Vitamin E
D. Vitamin D
61. Does scurvy occur due to a deficiency?
A. Vitamin k
B. Vitamin C
C. Vitamin A
D. Vitamin E
62. Which of the following vitamins acts as an Anti-oxidant?
A. Tocopherol (Beauty Vitamin) Vitamin E
B. Biotin (B7)
C. Retinol (A)
D. Calciferol (D)
63. Which vitamin is used as an antidote for warfarin Poisoning?
A. Vitamin K
B. Vitamin C
C. Vitamin A
D. Vitamin D
64. Deficiency of which vitamin may cause Osteomalacia?
A. Vitamin K (Phylloquinone)
B. Vitamin A (Retinol/Retinal/Retinoic acid)
C. Vitamin D (Calciferol)
D. Vitamin C (Ascorbic acid)
65. Does Beriberi occur due to a deficiency?
A. Vitamin K
B. Vitamin B1 (Thiamine)
C. Vitamin B3 (Niacin)
D. Vitamin B5 (Pantothenic Acid)
66. Pellagra(3D) occurred due to a deficiency.
A. Ascorbic acid (Vitamin C )
B. Pantothenic acid(Vitamin B5)
C. Niacin/Nicotinic acid (Vitamin B3)
D. Biotin (Vitamin B7)
67. What is the energy value of lipids?
A. 9.0 kcal/gm
B. 7.0 Kcal/gm (Alcohol)
C. 4.0 Kcal/gm (Carbohydrate/protein)
D. 5.0 Kcal/gm
68. Richest source of protein is?
A. Soya bean
B. Meat
C. Fish
D. Rice
69. Building blocks of protein is?
A. Sccharides
B. Carbohydrates
C. Aminoacids
D. Fatty acids
70. Renin is secreted by?
A. Liver
B. Kidney
C. Stomach (Rennin)
D. Lungs
71. The common side effect of ACE inhibitor( Enalapril) is?
A. Dry cough
B. Stomachache
C. Hyperuricaemia
72. Is ankle swelling the side effect?
A. Amitriptyline
B. Amlodipine
C. Famotidine
D. Omeprazole
73. Which of the following strengths of amlodipine is available in the Market?
A. 5mg, 10mg 15mg
B. 2.5mg, 5mg, 10 mg
C. 10mg, 20mg, 50 mg
D. 100mg, 200mg, 500mg
74. What is the route of administration of Nifedipine?
A. Oral
B. Sublingual
C. Subcutaneous
D. Rectal
75. Structure of which calcium channel blocker is similar to Benzodiazepines?
a. Diltiazem
b. Verapamil
c. Amlodipine
d. Nifedipine
76. What is the side effect of Frusemide?
a. Ankle swealing
b. Muscle cramp
c. Vomiting
d. Muscle weakness
77. Does acetazolamide act by blocking the enzyme?
a. Transpeptidase
b. Carbonic Anhydrase (USED IN MOUNTAIN SICKNESS)
c. Phospholipase
d. Cyclooxygenase
78. Propranolol is Contraindicated in?
a. Hypertension
b. Angina
c. Bronchial Asthma (Asthma is precipitated by: Propranolol)
d. Diabetes mellitus
79. Which of the following is a Short-acting beta-blocker?
A. Propranolol
B. Timolol
C. Esmolol
D. Atenolol
80. The drug of choice for hypertension in Pregnancy is?
a. Amlodipine
b. Frusemide
c. Methyldopa
d. Aliskiren
81. Which of the following Diuretics may cause the Gynaecomastia(Enlargement of breast in Male)?
a. Amiloride
b. Frusemide
c. Thiazide
d. Spironolactone (Ketoconazole/Cimedine)
82. Which diuretic is also known as the Most potent diuretic?
a. Thiazide
b. Frusemide
c. Amlodipine
d. Nifedipine
83. Osmotic diuretic is?
a. Mannitol
b. Frusemide
c. Spironolactone
d. Amiloride
84. Active form of Enalapril(Prodrug) is?
a. Enalaprilat
85. Which is an alternative drug for patients with hypersensitivity to ACE Blockers?
a. Losartan
b. Amlodipine
c. Spironolacton
d. Amiloride
86. Which of the following drugs has the shortest plasma half-life?
a. Sodium Nitroprusside (2-3 Minutes)
b. Amiloride
c. Amlodipine
d. Losartan
87. Which of the following is a plant derivative antihypertensive alkaloid?
a. Reserpine (MOA: Catecholamine Depletion)
b. Amlodipine
c. Methyldopa
d. Mannitol
88. Sulfonamide is obtained from?
a. Protosil
b. Prontosil (1935)
c. Fungus
d. Bacteria
89. Is Silversulfdiazine (Silver compounds) used for the management of?
A. Oral Infections
B. Cancer
C. Burning conditions
D. Diarrhoea
90. What is the ratio of sulphamethoxazole and trimethoprim in Cotrimoxazole?
A. 5:1
B. 6:2
C. 7:1
D. 1:7
91. Magic Bullet of Medicine is?
A. Tetracycline
B. Penicillin
C. Sulfonamides
D. Chloramphenicol
92. Is taking plenty of water (Liquids in adequate amounts) necessary counseling?
A. Penicillins
B. Cotrimoxazole
C. Tetracycline
D. Chloramphenicol
93. What is the common side effect seen under sulfonamide therapy/Cotrimoxazole?
A. Crystalureas
94. Steven Johnson syndrome is the side effect of?
a. Pantoprazole
b. Sulfonamide
c. Metronidazole
d. Penicillins
95. If you are under 3rd week of sulfonamide therapy and experience rashes in your skin. What type of hypersensitivity reaction is this?
96. Which drug is known as the queen of medicine?
A. Penicillin
B. Chloramphenicol
C. Tetracycline
D. Pantoprazole
97. Penicillin was invented in?
a.     1929AD (1928AD)
b. 1940AD
c. 1950AD
d. 1945AD
98. Father of antibiotics?
a. Alexender fleming
99. When was penicillin clinically used? 
a. 1929
b. 1941
c. 1945
d. 1948
100. Which of the following is natural penicillin?
a. Ampicillin
b. Benzylpenicillin( Penicillin G)
c. Amoxicillin
d. Cloxacillin

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